This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1i51

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1i51.gif|left|200px]]
[[Image:1i51.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1i51 |SIZE=350|CAPTION= <scene name='initialview01'>1i51</scene>, resolution 2.45&Aring;
+
The line below this paragraph, containing "STRUCTURE_1i51", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= CASP7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), XIAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1i51| PDB=1i51 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i51 OCA], [http://www.ebi.ac.uk/pdbsum/1i51 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i51 RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP'''
'''CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP'''
Line 30: Line 27:
[[Category: Chai, J.]]
[[Category: Chai, J.]]
[[Category: Shi, Y.]]
[[Category: Shi, Y.]]
-
[[Category: apoptosis]]
+
[[Category: Apoptosis]]
-
[[Category: caspase]]
+
[[Category: Caspase]]
-
[[Category: iap]]
+
[[Category: Iap]]
-
[[Category: protease]]
+
[[Category: Protease]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:34:57 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:14:42 2008''
+

Revision as of 16:34, 2 May 2008

Image:1i51.gif

Template:STRUCTURE 1i51

CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP


Contents

Overview

The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making extensive contacts to the residues that are essential for its catalytic activity. Strikingly, despite a reversal of relative orientation, a subset of interactions between caspase-7 and XIAP closely resemble those between caspase-7 and its tetrapeptide inhibitor DEVD-CHO. Our biochemical and structural analyses reveal that the BIR domains are dispensable for the inhibition of caspase-3 and -7. This study provides a structural basis for the design of the next-generation caspase inhibitors.

Disease

Known disease associated with this structure: Lymphoproliferative syndrome, X-linked, 2 OMIM:[300079]

About this Structure

1I51 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of caspase-7 inhibition by XIAP., Chai J, Shiozaki E, Srinivasula SM, Wu Q, Datta P, Alnemri ES, Shi Y, Cell. 2001 Mar 9;104(5):769-80. PMID:11257230 Page seeded by OCA on Fri May 2 19:34:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i51"
Personal tools