1i50

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[[Image:1i50.gif|left|200px]]
[[Image:1i50.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1i50 |SIZE=350|CAPTION= <scene name='initialview01'>1i50</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1i50", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1i50| PDB=1i50 | SCENE= }}
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|RELATEDENTRY=[[1en0|1EN0]], [[1i3q|1I3Q]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i50 OCA], [http://www.ebi.ac.uk/pdbsum/1i50 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i50 RCSB]</span>
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}}
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'''RNA POLYMERASE II CRYSTAL FORM II AT 2.8 A RESOLUTION'''
'''RNA POLYMERASE II CRYSTAL FORM II AT 2.8 A RESOLUTION'''
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[[Category: Cramer, P.]]
[[Category: Cramer, P.]]
[[Category: Kornberg, R D.]]
[[Category: Kornberg, R D.]]
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[[Category: molecular machine]]
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[[Category: Molecular machine]]
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[[Category: mrna]]
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[[Category: Mrna]]
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[[Category: multiprotein complex]]
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[[Category: Multiprotein complex]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: zinc motif]]
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[[Category: Zinc motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:34:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:14:43 2008''
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Revision as of 16:34, 2 May 2008

Image:1i50.gif

Template:STRUCTURE 1i50

RNA POLYMERASE II CRYSTAL FORM II AT 2.8 A RESOLUTION


Overview

Structures of a 10-subunit yeast RNA polymerase II have been derived from two crystal forms at 2.8 and 3.1 angstrom resolution. Comparison of the structures reveals a division of the polymerase into four mobile modules, including a clamp, shown previously to swing over the active center. In the 2.8 angstrom structure, the clamp is in an open state, allowing entry of straight promoter DNA for the initiation of transcription. Three loops extending from the clamp may play roles in RNA unwinding and DNA rewinding during transcription. A 2.8 angstrom difference Fourier map reveals two metal ions at the active site, one persistently bound and the other possibly exchangeable during RNA synthesis. The results also provide evidence for RNA exit in the vicinity of the carboxyl-terminal repeat domain, coupling synthesis to RNA processing by enzymes bound to this domain.

About this Structure

1I50 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution., Cramer P, Bushnell DA, Kornberg RD, Science. 2001 Jun 8;292(5523):1863-76. Epub 2001 Apr 19. PMID:11313498 Page seeded by OCA on Fri May 2 19:34:56 2008

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