1i7u

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[[Image:1i7u.jpg|left|200px]]
[[Image:1i7u.jpg|left|200px]]
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{{Structure
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|PDB= 1i7u |SIZE=350|CAPTION= <scene name='initialview01'>1i7u</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1i7u", creates the "Structure Box" on the page.
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|GENE= HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1i7u| PDB=1i7u | SCENE= }}
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|RELATEDENTRY=[[1i7r|1I7R]], [[1i7t|1I7T]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i7u OCA], [http://www.ebi.ac.uk/pdbsum/1i7u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i7u RCSB]</span>
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'''CRYSTAL STRUCTURE OF CLASS I MHC A2 IN COMPLEX WITH PEPTIDE P1049-6V'''
'''CRYSTAL STRUCTURE OF CLASS I MHC A2 IN COMPLEX WITH PEPTIDE P1049-6V'''
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[[Category: Loftus, D.]]
[[Category: Loftus, D.]]
[[Category: Zhao, R.]]
[[Category: Zhao, R.]]
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[[Category: mhc fold]]
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[[Category: Mhc fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:41:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:15:53 2008''
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Revision as of 16:41, 2 May 2008

Image:1i7u.jpg

Template:STRUCTURE 1i7u

CRYSTAL STRUCTURE OF CLASS I MHC A2 IN COMPLEX WITH PEPTIDE P1049-6V


Contents

Overview

Recognition of virally infected cells by CD8+ T cells requires differentiation between self and nonself peptide-class I major histocompatibility complexes (pMHC). Recognition of foreign pMHC by host T cells is a major factor in the rejection of transplanted organs from the same species (allotransplant) or different species (xenotransplant). AHIII12.2 is a murine T cell clone that recognizes the xenogeneic (human) class I MHC HLA-A2.1 molecule (A2) and the syngeneic murine class I MHC H-2 D(b) molecule (D(b)). Recognition of both A2 and D(b) are peptide-dependent, and the sequences of the peptides recognized have been determined. Alterations in the antigenic peptides bound to A2 cause large changes in AHIII12.2 T cell responsiveness. Crystal structures of three representative peptides (agonist, null, and antagonist) bound to A2 partially explain the changes in AHIII12.2 responsiveness. Using class I pMHC octamers, a strong correlation is seen between T cell activity and the affinity of pMHC complexes for the T cell receptor. However, contrary to previous studies, we see similar half-lives for the pMHC multimers bound to the AHIII12.2 cell surface.

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1I7U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

T cell activity correlates with oligomeric peptide-major histocompatibility complex binding on T cell surface., Buslepp J, Zhao R, Donnini D, Loftus D, Saad M, Appella E, Collins EJ, J Biol Chem. 2001 Dec 14;276(50):47320-8. Epub 2001 Oct 2. PMID:11584024 Page seeded by OCA on Fri May 2 19:41:04 2008

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