1ia0

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[[Image:1ia0.gif|left|200px]]
[[Image:1ia0.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ia0 |SIZE=350|CAPTION= <scene name='initialview01'>1ia0</scene>, resolution 15.&Aring;
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The line below this paragraph, containing "STRUCTURE_1ia0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5&#39;-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TXL:TAXOTERE'>TXL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= KIF1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_1ia0| PDB=1ia0 | SCENE= }}
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|RELATEDENTRY=[[1tub|1tub]], [[1i6i|1i6i]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ia0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ia0 OCA], [http://www.ebi.ac.uk/pdbsum/1ia0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ia0 RCSB]</span>
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}}
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'''KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM'''
'''KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM'''
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[[Category: Sablin, E P.]]
[[Category: Sablin, E P.]]
[[Category: Yajima, H.]]
[[Category: Yajima, H.]]
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[[Category: cryo-electron microscopy]]
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[[Category: Cryo-electron microscopy]]
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[[Category: fitting of x-ray structures into cryo-em reconstruction]]
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[[Category: Fitting of x-ray structures into cryo-em reconstruction]]
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[[Category: kif1a]]
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[[Category: Kif1a]]
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[[Category: microtubule]]
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[[Category: Microtubule]]
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[[Category: tubulin]]
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[[Category: Tubulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:45:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:16:47 2008''
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Revision as of 16:45, 2 May 2008

Image:1ia0.gif

Template:STRUCTURE 1ia0

KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM


Overview

Kinesin motors are specialized enzymes that use hydrolysis of ATP to generate force and movement along their cellular tracks, the microtubules. Although numerous biochemical and biophysical studies have accumulated much data that link microtubule-assisted ATP hydrolysis to kinesin motion, the structural view of kinesin movement remains unclear. This study of the monomeric kinesin motor KIF1A combines X-ray crystallography and cryo-electron microscopy, and allows analysis of force-generating conformational changes at atomic resolution. The motor is revealed in its two functionally critical states-complexed with ADP and with a non-hydrolysable analogue of ATP. The conformational change observed between the ADP-bound and the ATP-like structures of the KIF1A catalytic core is modular, extends to all kinesins and is similar to the conformational change used by myosin motors and G proteins. Docking of the ADP-bound and ATP-like crystallographic models of KIF1A into the corresponding cryo-electron microscopy maps suggests a rationale for the plus-end directional bias associated with the kinesin catalytic core.

About this Structure

1IA0 is a Protein complex structure of sequences from Mus musculus and Sus scrofa. Full crystallographic information is available from OCA.

Reference

Switch-based mechanism of kinesin motors., Kikkawa M, Sablin EP, Okada Y, Yajima H, Fletterick RJ, Hirokawa N, Nature. 2001 May 24;411(6836):439-45. PMID:11373668 Page seeded by OCA on Fri May 2 19:45:25 2008

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