1ib2

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[[Image:1ib2.gif|left|200px]]
[[Image:1ib2.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1ib2| PDB=1ib2 | SCENE= }}
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|RELATEDENTRY=[[1ib3|1IB3]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ib2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ib2 OCA], [http://www.ebi.ac.uk/pdbsum/1ib2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ib2 RCSB]</span>
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'''CRYSTAL STRUCTURE OF A PUMILIO-HOMOLOGY DOMAIN'''
'''CRYSTAL STRUCTURE OF A PUMILIO-HOMOLOGY DOMAIN'''
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[[Category: Wang, X.]]
[[Category: Wang, X.]]
[[Category: Zamore, P D.]]
[[Category: Zamore, P D.]]
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[[Category: pumilio-homology domain,puf motif]]
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[[Category: Pumilio-homology domain,puf motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:47:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:17:15 2008''
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Revision as of 16:47, 2 May 2008

Image:1ib2.gif

Template:STRUCTURE 1ib2

CRYSTAL STRUCTURE OF A PUMILIO-HOMOLOGY DOMAIN


Overview

Puf proteins regulate translation and mRNA stability by binding sequences in their target RNAs through the Pumilio homology domain (PUM-HD), which is characterized by eight tandem copies of a 36 amino acid motif, the PUM repeat. We have solved the structure of the PUM-HD from human Pumilio1 at 1.9 A resolution. The structure reveals that the eight PUM repeats correspond to eight copies of a single, repeated structural motif. The PUM repeats pack together to form a right-handed superhelix that approximates a half doughnut. The distribution of side chains on the inner and outer faces of this half doughnut suggests that the inner face of the PUM-HD binds RNA while the outer face interacts with proteins such as Nanos, Brain Tumor, and cytoplasmic polyadenylation element binding protein.

About this Structure

1IB2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Pumilio homology domain., Wang X, Zamore PD, Hall TM, Mol Cell. 2001 Apr;7(4):855-65. PMID:11336708 Page seeded by OCA on Fri May 2 19:47:37 2008

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