5eth

From Proteopedia

(Difference between revisions)

Revision as of 17:25, 12 July 2016

RORy in complex with inverse agonist 3.

Structural highlights

5eth is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.

Publication Abstract from PubMed

RORgamma plays a critical role in controlling a pro-inflammatory gene expression program in several lymphocyte lineages including T cells, gammadelta T cells, and innate lymphoid cells. RORgamma-mediated inflammation has been linked to susceptibility to Crohn's disease, arthritis, and psoriasis. Thus inverse agonists of RORgamma have the potential of modulating inflammation. Our goal was to optimize two RORgamma inverse agonists: T0901317 from literature and 1 that we obtained from internal screening. We used information from internal X-ray structures to design two libraries that led to a new biaryl series.

Discovery of biaryls as RORgamma inverse agonists by using structure-based design.,Enyedy IJ, Powell NA, Caravella J, van Vloten K, Chao J, Banerjee D, Marcotte D, Silvian L, McKenzie A, Hong VS, Fontenot JD Bioorg Med Chem Lett. 2016 Apr 1. pii: S0960-894X(16)30341-9. doi:, 10.1016/j.bmcl.2016.03.109. PMID:27080181^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Enyedy IJ, Powell NA, Caravella J, van Vloten K, Chao J, Banerjee D, Marcotte D, Silvian L, McKenzie A, Hong VS, Fontenot JD. Discovery of biaryls as RORgamma inverse agonists by using structure-based design. Bioorg Med Chem Lett. 2016 Apr 1. pii: S0960-894X(16)30341-9. doi:, 10.1016/j.bmcl.2016.03.109. PMID:27080181 doi:http://dx.doi.org/10.1016/j.bmcl.2016.03.109

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5eth"

Categories: Marcotte, D M | Inverse agonist | Ror gamma | Transcription

@@ Line 5: / Line 5: @@
 <table><tr><td colspan='2'>[[5eth]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ETH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ETH FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5RT:1-METHYL-~{N}-(1-THIOPHEN-2-YLCARBONYL-3,4-DIHYDRO-2~{H}-QUINOLIN-6-YL)-~{N}-[2,2,2-TRIS(FLUORANYL)ETHYL]INDOLE-4-SULFONAMIDE'>5RT</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eth OCA], [http://pdbe.org/5eth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eth RCSB], [http://www.ebi.ac.uk/pdbsum/5eth PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eth OCA], [http://pdbe.org/5eth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eth RCSB], [http://www.ebi.ac.uk/pdbsum/5eth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eth ProSAT]</span></td></tr>
 </table>
 == Function ==

5eth

From Proteopedia

Revision as of 17:25, 12 July 2016

RORy in complex with inverse agonist 3.

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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