1id1
From Proteopedia
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'''CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL''' | '''CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL''' | ||
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[[Category: MacKinnon, R.]] | [[Category: MacKinnon, R.]] | ||
[[Category: Pico, A.]] | [[Category: Pico, A.]] | ||
| - | [[Category: | + | [[Category: Bk channel]] |
| - | [[Category: | + | [[Category: E coli potassium channel]] |
| - | [[Category: | + | [[Category: Rck domain]] |
| - | [[Category: | + | [[Category: Rossmann fold]] |
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Revision as of 16:51, 2 May 2008
CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL
Overview
The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K+ transporters and K+ channels. The RCK domain has a Rossmann-fold topology with unique positions, not commonly conserved among Rossmann-fold proteins, composing a well-conserved salt bridge and a hydrophobic dimer interface. Structure-based amino acid sequence alignments and mutational analysis are used to demonstrate that an RCK domain is also present and is an important component of the gating machinery in eukaryotic large-conductance Ca2+ activated K+ channels.
About this Structure
1ID1 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel., Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R, Neuron. 2001 Mar;29(3):593-601. PMID:11301020 Page seeded by OCA on Fri May 2 19:51:40 2008
