5hkn
From Proteopedia
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==Crystal structure de novo designed fullerene organizing protein complex with fullerene== | ==Crystal structure de novo designed fullerene organizing protein complex with fullerene== | ||
| - | <StructureSection load='5hkn' size='340' side='right' caption='[[5hkn]], [[Resolution|resolution]] 1.76Å' scene=''> | + | <StructureSection load='5hkn' size='340' side='right'caption='[[5hkn]], [[Resolution|resolution]] 1.76Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5hkn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HKN FirstGlance]. <br> | <table><tr><td colspan='2'>[[5hkn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HKN FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=60C:(C_{60}-I_{H})[5,6]FULLERENE'>60C</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=60C:(C_{60}-I_{H})[5,6]FULLERENE'>60C</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hkr|5hkr]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hkr|5hkr]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hkn OCA], [http://pdbe.org/5hkn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hkn RCSB], [http://www.ebi.ac.uk/pdbsum/5hkn PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hkn OCA], [http://pdbe.org/5hkn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hkn RCSB], [http://www.ebi.ac.uk/pdbsum/5hkn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hkn ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Learning to engineer self-assembly would enable the precise organization of molecules by design to create matter with tailored properties. Here we demonstrate that proteins can direct the self-assembly of buckminsterfullerene (C60) into ordered superstructures. A previously engineered tetrameric helical bundle binds C60 in solution, rendering it water soluble. Two tetramers associate with one C60, promoting further organization revealed in a 1.67-A crystal structure. Fullerene groups occupy periodic lattice sites, sandwiched between two Tyr residues from adjacent tetramers. Strikingly, the assembly exhibits high charge conductance, whereas both the protein-alone crystal and amorphous C60 are electrically insulating. The affinity of C60 for its crystal-binding site is estimated to be in the nanomolar range, with lattices of known protein crystals geometrically compatible with incorporating the motif. Taken together, these findings suggest a new means of organizing fullerene molecules into a rich variety of lattices to generate new properties by design. | ||
| + | |||
| + | Protein-directed self-assembly of a fullerene crystal.,Kim KH, Ko DK, Kim YT, Kim NH, Paul J, Zhang SQ, Murray CB, Acharya R, DeGrado WF, Kim YH, Grigoryan G Nat Commun. 2016 Apr 26;7:11429. doi: 10.1038/ncomms11429. PMID:27113637<ref>PMID:27113637</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5hkn" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Acharya, R]] | [[Category: Acharya, R]] | ||
[[Category: DeGardo, W F]] | [[Category: DeGardo, W F]] | ||
Revision as of 08:58, 1 January 2020
Crystal structure de novo designed fullerene organizing protein complex with fullerene
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