NF-kB
From Proteopedia
(Difference between revisions)
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*'''NF-kB1''' (synthesized as '''p105''' and processed to '''p50''')<br /> | *'''NF-kB1''' (synthesized as '''p105''' and processed to '''p50''')<br /> | ||
*'''NF-kB2''' (synthesized as '''p100''' and processed to '''p52''')<br /> | *'''NF-kB2''' (synthesized as '''p100''' and processed to '''p52''')<br /> | ||
| - | *'''RelA''' (or '''p65''')<br /> | + | *'''RelA''' (or '''p65''' subunit of NF-kB)<br /> |
*'''RelB'''<br /> | *'''RelB'''<br /> | ||
*'''cRel'''. | *'''cRel'''. | ||
== Relevance == | == Relevance == | ||
| - | NF-kB plays a critical role in cancer development and progression and may determine its response to therapy. NF-kB is a target for chemotherapeutic agents<ref>PMID:16673382</ref>. | + | NF-kB plays a critical role in cancer development and progression and may determine its response to therapy. NF-kB is a target for chemotherapeutic agents<ref>PMID:16673382</ref>. NF-kB is a critical link between inflammation and cancer<ref>PMID:20066113</ref>. |
</StructureSection> | </StructureSection> | ||
Revision as of 06:55, 15 May 2016
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3D structures of NF-kappaB
Updated on 15-May-2016
References
- ↑ Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev. 2004 Sep 15;18(18):2195-224. PMID:15371334 doi:http://dx.doi.org/10.1101/gad.1228704
- ↑ Karin M. NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 2006 Jun;45(6):355-61. PMID:16673382 doi:http://dx.doi.org/10.1002/mc.20217
- ↑ Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a000141. doi:, 10.1101/cshperspect.a000141. PMID:20066113 doi:http://dx.doi.org/10.1101/cshperspect.a000141
