Nitroreductase
From Proteopedia
(Difference between revisions)
| Line 5: | Line 5: | ||
== Relevance == | == Relevance == | ||
| - | NR is of special interest due to its potential use as activator of prodrugs in cancer therapy. | + | NR is of special interest due to its potential use as activator of prodrugs in cancer therapy<ref>PMID:26431849</ref>. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 10:11, 15 May 2016
| |||||||||||
3D structures of nitroreductase
Updated on 15-May-2016
References
- ↑ Lovering AL, Hyde EI, Searle PF, White SA. The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution. J Mol Biol. 2001 May 25;309(1):203-13. PMID:11491290 doi:10.1006/jmbi.2001.4653
- ↑ Williams EM, Little RF, Mowday AM, Rich MH, Chan-Hyams JV, Copp JN, Smaill JB, Patterson AV, Ackerley DF. Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility. Biochem J. 2015 Oct 15;471(2):131-53. doi: 10.1042/BJ20150650. PMID:26431849 doi:http://dx.doi.org/10.1042/BJ20150650
