4z33

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'''Unreleased structure'''
 
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The entry 4z33 is ON HOLD until Paper Publication
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==Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2==
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<StructureSection load='4z33' size='340' side='right' caption='[[4z33]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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Authors: Egea-Jimenez, A.L., Gallardo, R., Garcia-Pino, A., Ivarsson, Y., Wawrzyniak, A.M., Kashyap, R., Loris, R., Schymkowitz, J., Rousseau, F., Zimmermann, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4z33]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z33 FirstGlance]. <br>
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Description: Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IP2:D-MYO-INOSITOL-4,5-BISPHOSPHATE'>IP2</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1n99|1n99]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z33 OCA], [http://pdbe.org/4z33 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z33 RCSB], [http://www.ebi.ac.uk/pdbsum/4z33 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z33 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SDCB1_HUMAN SDCB1_HUMAN]] Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.<ref>PMID:10230395</ref> <ref>PMID:11179419</ref> <ref>PMID:11498591</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Egea-Jimenez, A L]]
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[[Category: Gallardo, R]]
[[Category: Garcia-Pino, A]]
[[Category: Garcia-Pino, A]]
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[[Category: Ivarsson, Y]]
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[[Category: Kashyap, R]]
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[[Category: Loris, R]]
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[[Category: Rousseau, F]]
[[Category: Schymkowitz, J]]
[[Category: Schymkowitz, J]]
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[[Category: Loris, R]]
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[[Category: Wawrzyniak, A M]]
[[Category: Zimmermann, P]]
[[Category: Zimmermann, P]]
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[[Category: Ivarsson, Y]]
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[[Category: Frizzle 7]]
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[[Category: Rousseau, F]]
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[[Category: Pdz]]
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[[Category: Kashyap, R]]
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[[Category: Pip2]]
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[[Category: Wawrzyniak, A.M]]
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[[Category: Signaling protein]]
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[[Category: Egea-Jimenez, A.L]]
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[[Category: Syntenin]]
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[[Category: Gallardo, R]]
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Revision as of 10:13, 13 July 2016

Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2

4z33, resolution 2.45Å

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