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5cpr
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity== |
| - | + | <StructureSection load='5cpr' size='340' side='right' caption='[[5cpr]], [[Resolution|resolution]] 2.22Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5cpr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CPR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=539:6,7-DICHLORO-N-CYCLOPENTYL-4-(PYRIDIN-4-YL)PHTHALAZIN-1-AMINE'>539</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cpr OCA], [http://pdbe.org/5cpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cpr RCSB], [http://www.ebi.ac.uk/pdbsum/5cpr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cpr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SV421_HUMAN SV421_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Histone-lysine N-methyltransferase]] | ||
| + | [[Category: Jakob, C G]] | ||
| + | [[Category: Sun, C]] | ||
| + | [[Category: Upadhyay, A K]] | ||
| + | [[Category: H4k20]] | ||
| + | [[Category: Non-homologous end joining]] | ||
| + | [[Category: Protein lysine transferase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 23:38, 25 January 2017
The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
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