5dim
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Mutant toxin in 'native' space group== | |
| - | + | <StructureSection load='5dim' size='340' side='right' caption='[[5dim]], [[Resolution|resolution]] 3.32Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5dim]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DIM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dim OCA], [http://pdbe.org/5dim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dim RCSB], [http://www.ebi.ac.uk/pdbsum/5dim PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dim ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TACY_CLOPE TACY_CLOPE]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation.<ref>PMID:17328912</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gorman, M A]] | ||
| + | [[Category: Lawrence, S L]] | ||
| + | [[Category: Parker, M W]] | ||
| + | [[Category: Mutant]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 19:44, 9 December 2016
Mutant toxin in 'native' space group
| |||||||||||
Categories: Gorman, M A | Lawrence, S L | Parker, M W | Mutant | Toxin
