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5e6b

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'''Unreleased structure'''
 
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The entry 5e6b is ON HOLD until Paper Publication
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==Glucocorticoid receptor DNA binding domain - RELB NF-kB response element complex==
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<StructureSection load='5e6b' size='340' side='right' caption='[[5e6b]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5e6b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E6B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E6B FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e69|5e69]], [[5e6a|5e6a]], [[5e6c|5e6c]], [[5e6d|5e6d]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e6b OCA], [http://pdbe.org/5e6b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e6b RCSB], [http://www.ebi.ac.uk/pdbsum/5e6b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e6b ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Herbst, A G]]
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[[Category: Hudson, W H]]
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[[Category: Ortlund, E A]]
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[[Category: Rye, E A]]
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[[Category: Dna binding protein]]
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[[Category: Dna binding protein-dna complex]]

Revision as of 09:21, 10 March 2017

Glucocorticoid receptor DNA binding domain - RELB NF-kB response element complex

5e6b, resolution 2.25Å

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