1ig3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ig3.gif|left|200px]]
[[Image:1ig3.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ig3 |SIZE=350|CAPTION= <scene name='initialview01'>1ig3</scene>, resolution 1.90&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ig3", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VIB:3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM'>VIB</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine_diphosphokinase Thiamine diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.2 2.7.6.2] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ig3| PDB=1ig3 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ig3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ig3 OCA], [http://www.ebi.ac.uk/pdbsum/1ig3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ig3 RCSB]</span>
+
-
}}
+
'''Mouse Thiamin Pyrophosphokinase Complexed with Thiamin'''
'''Mouse Thiamin Pyrophosphokinase Complexed with Thiamin'''
Line 30: Line 27:
[[Category: Liu, J.]]
[[Category: Liu, J.]]
[[Category: Timm, D E.]]
[[Category: Timm, D E.]]
-
[[Category: alpha/beta/alpha sandwich]]
+
[[Category: Alpha/beta/alpha sandwich]]
-
[[Category: beta barrel]]
+
[[Category: Beta barrel]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:57:45 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:19:17 2008''
+

Revision as of 16:57, 2 May 2008

Image:1ig3.gif

Template:STRUCTURE 1ig3

Mouse Thiamin Pyrophosphokinase Complexed with Thiamin


Overview

Thiamin pyrophosphate (TPP) is a coenzyme derived from vitamin B1 (thiamin). TPP synthesis in eukaryotes requires thiamin pyrophosphokinase (TPK), which catalyzes the transfer of a pyrophosphate group from ATP to thiamin. TPP is essential for central metabolic processes, including the formation of acetyl CoA from glucose and the Krebs cycle. Deficiencies in human thiamin metabolism result in beriberi and Wernicke encephalopathy. The crystal structure of mouse TPK was determined by multiwavelength anomalous diffraction at 2.4 A resolution, and the structure of TPK complexed with thiamin has been refined at 1.9 A resolution. The TPK polypeptide folds as an alpha/beta-domain and a beta-sandwich domain, which share a central ten-stranded mixed beta-sheet. TPK subunits associate as a dimer, and thiamin is bound in the dimer interface. Despite lacking apparent sequence homology with other proteins, the alpha/beta-domain resembles the Rossman fold and is similar to other kinase structures, including another pyrophosphokinase and a thiamin biosynthetic enzyme. Comparison of mouse and yeast TPK structures reveals differences that could be exploited in developing species-specific inhibitors of potential use as antimicrobial agents.

About this Structure

1IG3 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of thiamin pyrophosphokinase., Timm DE, Liu J, Baker LJ, Harris RA, J Mol Biol. 2001 Jun 29;310(1):195-204. PMID:11419946 Page seeded by OCA on Fri May 2 19:57:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ig3"
Personal tools