1ig7

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[[Image:1ig7.gif|left|200px]]
[[Image:1ig7.gif|left|200px]]
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{{Structure
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|PDB= 1ig7 |SIZE=350|CAPTION= <scene name='initialview01'>1ig7</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1ig7", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_1ig7| PDB=1ig7 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ig7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ig7 OCA], [http://www.ebi.ac.uk/pdbsum/1ig7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ig7 RCSB]</span>
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'''Msx-1 Homeodomain/DNA Complex Structure'''
'''Msx-1 Homeodomain/DNA Complex Structure'''
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[[Category: Geiger, J H.]]
[[Category: Geiger, J H.]]
[[Category: Hovde, S.]]
[[Category: Hovde, S.]]
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[[Category: helix-turn-helix]]
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[[Category: Helix-turn-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:57:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:19:22 2008''
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Revision as of 16:57, 2 May 2008

Image:1ig7.gif

Template:STRUCTURE 1ig7

Msx-1 Homeodomain/DNA Complex Structure


Overview

The Msx-1 homeodomain protein plays a crucial role in craniofacial, limb, and nervous system development. Homeodomain DNA-binding domains are comprised of 60 amino acids that show a high degree of evolutionary conservation. We have determined the structure of the Msx-1 homeodomain complexed to DNA at 2.2 A resolution. The structure has an unusually well-ordered N-terminal arm with a unique trajectory across the minor groove of the DNA. DNA specificity conferred by bases flanking the core TAAT sequence is explained by well ordered water-mediated interactions at Q50. Most interactions seen at the TAAT sequence are typical of the interactions seen in other homeodomain structures. Comparison of the Msx-1-HD structure to all other high resolution HD-DNA complex structures indicate a remarkably well-conserved sphere of hydration between the DNA and protein in these complexes.

About this Structure

1IG7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Msx-1 homeodomain/DNA complex., Hovde S, Abate-Shen C, Geiger JH, Biochemistry. 2001 Oct 9;40(40):12013-21. PMID:11580277 Page seeded by OCA on Fri May 2 19:57:55 2008

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