1igj

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[[Image:1igj.gif|left|200px]]
[[Image:1igj.gif|left|200px]]
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{{Structure
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|PDB= 1igj |SIZE=350|CAPTION= <scene name='initialview01'>1igj</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1igj", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DGX:DIGOXIN'>DGX</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1igj| PDB=1igj | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1igj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1igj OCA], [http://www.ebi.ac.uk/pdbsum/1igj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1igj RCSB]</span>
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}}
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'''26-10 FAB:DIGOXIN COMPLEX-AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY'''
'''26-10 FAB:DIGOXIN COMPLEX-AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY'''
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==About this Structure==
==About this Structure==
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1IGJ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IGJ OCA].
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1IGJ is a [[Protein complex]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IGJ OCA].
==Reference==
==Reference==
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[[Category: Jeffrey, P D.]]
[[Category: Jeffrey, P D.]]
[[Category: Sheriff, S.]]
[[Category: Sheriff, S.]]
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[[Category: immunoglobulin]]
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[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:58:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:19:29 2008''
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Revision as of 16:58, 2 May 2008

Image:1igj.gif

Template:STRUCTURE 1igj

26-10 FAB:DIGOXIN COMPLEX-AFFINITY AND SPECIFICITY DUE TO SURFACE COMPLEMENTARITY


Overview

We have determined the three-dimensional structures of the antigen-binding fragment of the anti-digoxin monoclonal antibody 26-10 in the uncomplexed state at 2.7 A resolution and as a complex with digoxin at 2.5 A resolution. Neither the antibody nor digoxin undergoes any significant conformational changes upon forming the complex. Digoxin interacts primarily with the antibody heavy chain and is oriented such that the carbohydrate groups are exposed to solvent and the lactone ring is buried in a deep pocket at the bottom of the combining site. Despite extensive interactions between antibody and antigen, no hydrogen bonds or salt links are formed between 26-10 and digoxin. Thus the 26-10-digoxin complex is unique among the known three-dimensional structures of antibody-antigen complexes in that specificity and high affinity arise primarily from shape complementarity.

About this Structure

1IGJ is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

26-10 Fab-digoxin complex: affinity and specificity due to surface complementarity., Jeffrey PD, Strong RK, Sieker LC, Chang CY, Campbell RL, Petsko GA, Haber E, Margolies MN, Sheriff S, Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10310-4. PMID:8234291 Page seeded by OCA on Fri May 2 19:58:28 2008

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