5hj2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Integrin alpha2beta1 I-domain== | |
| - | + | <StructureSection load='5hj2' size='340' side='right' caption='[[5hj2]], [[Resolution|resolution]] 2.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hj2]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HJ2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hgj|5hgj]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hj2 OCA], [http://pdbe.org/5hj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hj2 RCSB], [http://www.ebi.ac.uk/pdbsum/5hj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hj2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ITA2_HUMAN ITA2_HUMAN]] Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Banerjee, S]] | ||
| + | [[Category: Brown, K L]] | ||
| + | [[Category: Adhesion]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Signaling]] | ||
Revision as of 11:41, 12 April 2017
Integrin alpha2beta1 I-domain
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