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1ih6
From Proteopedia
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[[Image:1ih6.gif|left|200px]] | [[Image:1ih6.gif|left|200px]] | ||
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'''Multi-Conformation Crystal Structure of GGBr5CGCC''' | '''Multi-Conformation Crystal Structure of GGBr5CGCC''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH6 OCA]. | |
==Reference== | ==Reference== | ||
A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11390969 11390969] | A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11390969 11390969] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Henderson, K.]] | [[Category: Henderson, K.]] | ||
[[Category: Ho, P S.]] | [[Category: Ho, P S.]] | ||
[[Category: Vargason, J M.]] | [[Category: Vargason, J M.]] | ||
| - | [[Category: | + | [[Category: B to a dna transition]] |
| - | [[Category: | + | [[Category: Dna transition]] |
| - | [[Category: | + | [[Category: Structural transition]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:59:40 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 16:59, 2 May 2008
Multi-Conformation Crystal Structure of GGBr5CGCC
Overview
The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.
About this Structure
Full crystallographic information is available from OCA.
Reference
A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969 Page seeded by OCA on Fri May 2 19:59:40 2008
