1ih6

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[[Image:1ih6.gif|left|200px]]
[[Image:1ih6.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ih6 |SIZE=350|CAPTION= <scene name='initialview01'>1ih6</scene>, resolution 1.45&Aring;
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The line below this paragraph, containing "STRUCTURE_1ih6", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CBR:5-BROMO-2&#39;-DEOXY-CYTIDINE-5&#39;-MONOPHOSPHATE'>CBR</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1ih6| PDB=1ih6 | SCENE= }}
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|RELATEDENTRY=[[1ih1|1IH1]], [[1ih2|1IH2]], [[1ih3|1IH3]], [[1ih4|1IH4]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ih6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ih6 OCA], [http://www.ebi.ac.uk/pdbsum/1ih6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ih6 RCSB]</span>
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}}
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'''Multi-Conformation Crystal Structure of GGBr5CGCC'''
'''Multi-Conformation Crystal Structure of GGBr5CGCC'''
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==About this Structure==
==About this Structure==
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1IH6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH6 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IH6 OCA].
==Reference==
==Reference==
A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11390969 11390969]
A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11390969 11390969]
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[[Category: Protein complex]]
 
[[Category: Henderson, K.]]
[[Category: Henderson, K.]]
[[Category: Ho, P S.]]
[[Category: Ho, P S.]]
[[Category: Vargason, J M.]]
[[Category: Vargason, J M.]]
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[[Category: b to a dna transition]]
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[[Category: B to a dna transition]]
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[[Category: dna transition]]
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[[Category: Dna transition]]
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[[Category: structural transition]]
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[[Category: Structural transition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:59:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:19:42 2008''
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Revision as of 16:59, 2 May 2008

Image:1ih6.gif

Template:STRUCTURE 1ih6

Multi-Conformation Crystal Structure of GGBr5CGCC


Overview

The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.

About this Structure

Full crystallographic information is available from OCA.

Reference

A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969 Page seeded by OCA on Fri May 2 19:59:40 2008

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