5ils
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Autoinhibited ETV1== |
| - | + | <StructureSection load='5ils' size='340' side='right' caption='[[5ils]], [[Resolution|resolution]] 1.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ils]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ILS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ILS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ilu|5ilu]], [[5ilv|5ilv]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ils FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ils OCA], [http://pdbe.org/5ils PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ils RCSB], [http://www.ebi.ac.uk/pdbsum/5ils PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ils ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/ETV1_HUMAN ETV1_HUMAN]] Ewing sarcoma. Ewing sarcoma (ES) [MIM:[http://omim.org/entry/612219 612219]]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ETV1_HUMAN ETV1_HUMAN]] Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Currie, S L]] | ||
| + | [[Category: Whitby, F G]] | ||
| + | [[Category: Autoinhibition transcription]] | ||
| + | [[Category: Dna binding]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Et]] | ||
| + | [[Category: Etv1]] | ||
| + | [[Category: Transcription factor]] | ||
Revision as of 01:34, 11 March 2017
Autoinhibited ETV1
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