5iqz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of N-terminal domain of Human SIRT7== | |
| + | <StructureSection load='5iqz' size='340' side='right' caption='[[5iqz]], [[Resolution|resolution]] 2.33Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5iqz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IQZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iqz OCA], [http://pdbe.org/5iqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iqz RCSB], [http://www.ebi.ac.uk/pdbsum/5iqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iqz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Human SIRT7 is an NAD+ dependent deacetylase which belongs to sirtuin family of proteins. SIRT7, like other sirtuins has conserved catalytic domain and is flanked by N- and C- terminal domains reported to play vital functional roles. Here, we report the crystal structure of the N-terminal domain of human SIRT7 (SIRT7NTD ) at 2.3 A resolution as MBP-SIRT7NTD fusion protein. SIRT7NTD adopts three-helical domain architecture and comparative structural analyses suggest similarities to some DNA binding motifs and transcription regulators. We also report here the importance of N- and C-terminal domains in soluble expression of SIRT7. This article is protected by copyright. All rights reserved. | ||
| - | + | Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture.,Priyanka A, Solanki V, Parkesh R, Thakur KG Proteins. 2016 Jun 10. doi: 10.1002/prot.25085. PMID:27287224<ref>PMID:27287224</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5iqz" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Priyanka, A]] | ||
| + | [[Category: Thakur, K G]] | ||
| + | [[Category: Alpha histone deacetylase sirtuin]] | ||
| + | [[Category: Fusion protein]] | ||
| + | [[Category: Maltose binding]] | ||
| + | [[Category: Sirt7]] | ||
| + | [[Category: Sugar binding protein]] | ||
Revision as of 15:44, 27 July 2016
Crystal structure of N-terminal domain of Human SIRT7
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