5j81
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Glycoprotein C from Puumala virus in the post-fusion conformation (pH 6.0)== | |
| - | + | <StructureSection load='5j81' size='340' side='right' caption='[[5j81]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5j81]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J81 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j81 OCA], [http://pdbe.org/5j81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j81 RCSB], [http://www.ebi.ac.uk/pdbsum/5j81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j81 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GP_PUUMP GP_PUUMP]] Glycoprotein N and Glycoprotein C interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Glycoprotein N contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dessau, M]] | ||
| + | [[Category: Willensky, S]] | ||
| + | [[Category: Class ii]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Membrane fusion]] | ||
| + | [[Category: Viral protein]] | ||
| + | [[Category: Virus]] | ||
Revision as of 21:29, 5 October 2016
Crystal structure of Glycoprotein C from Puumala virus in the post-fusion conformation (pH 6.0)
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