5jkd

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'''Unreleased structure'''
 
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The entry 5jkd is ON HOLD until Paper Publication
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==Crystal structure of human IZUMO1-JUNO complex (crystal form 2)==
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<StructureSection load='5jkd' size='340' side='right' caption='[[5jkd]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors: Ohto, U., Ishida, H., Shimizu, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5jkd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JKD FirstGlance]. <br>
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Description: Crystal structure of human IZUMO1-JUNO complex (crystal form 2)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jke|5jke]], [[5jkc|5jkc]], [[5jkb|5jkb]], [[5jka|5jka]], [[5jk9|5jk9]]</td></tr>
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[[Category: Shimizu, T]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jkd OCA], [http://pdbe.org/5jkd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jkd RCSB], [http://www.ebi.ac.uk/pdbsum/5jkd PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/IZUM1_HUMAN IZUM1_HUMAN]] Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.<ref>PMID:15759005</ref> [[http://www.uniprot.org/uniprot/JUNO_HUMAN JUNO_HUMAN]] Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.[UniProtKB:Q9EQF4]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Ishida, H]]
[[Category: Ishida, H]]
[[Category: Ohto, U]]
[[Category: Ohto, U]]
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[[Category: Shimizu, T]]
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[[Category: Cell adhesion]]
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[[Category: Fertilization]]
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[[Category: Izumo1]]
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[[Category: Juno]]

Revision as of 23:29, 23 June 2016

Crystal structure of human IZUMO1-JUNO complex (crystal form 2)

5jkd, resolution 2.90Å

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