1ik3

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[[Image:1ik3.jpg|left|200px]]
[[Image:1ik3.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ik3 |SIZE=350|CAPTION= <scene name='initialview01'>1ik3</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1ik3", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=FE3:Fe+(Fe+3)+Active+Site'>FE3</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=11O:(TRANS-12,13-EPOXY)-11-HYDROXY-9(Z)-OCTADECENOIC+ACID'>11O</scene>, <scene name='pdbligand=13R:13(R)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC+ACID'>13R</scene>, <scene name='pdbligand=13S:13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC+ACID'>13S</scene>, <scene name='pdbligand=9OH:(TRANS-12,13-EPOXY)-9-HYDROXY-10(E)-OCTADECENOIC+ACID'>9OH</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1ik3| PDB=1ik3 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ik3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ik3 OCA], [http://www.ebi.ac.uk/pdbsum/1ik3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ik3 RCSB]</span>
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}}
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'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID'''
'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID'''
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[[Category: Jr., M O.Funk.]]
[[Category: Jr., M O.Funk.]]
[[Category: Skrzypczak-Jankun, E.]]
[[Category: Skrzypczak-Jankun, E.]]
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[[Category: fe(iii) complex]]
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[[Category: Interm]]
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[[Category: interm]]
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[[Category: Oxidoreductase]]
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[[Category: oxidoreductase]]
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[[Category: Purple lipoxygenase]]
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[[Category: purple lipoxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:05:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:20:51 2008''
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Revision as of 17:05, 2 May 2008

Image:1ik3.jpg

Template:STRUCTURE 1ik3

LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID


Overview

Polyunsaturated fatty acid metabolism is governed primarily by two enzymes, prostaglandin H synthase and lipoxygenase. The crystal structure of the metastable product-oxidized purple form of soybean lipoxygenase-3 was determined at 2.0 A resolution. The data reveal that the chromophore corresponds to an iron-peroxide complex, a potential intermediate in the catalyzed reaction. A significant alteration of the iron site accompanies the formation of the complex. The structure, the first for a fatty acid-lipoxygenase complex, also reveals an unexpected mode of binding, and identifies amino acid residues that may play significant roles in catalysis, regio- and stereoselectivity.

About this Structure

1IK3 is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of a purple lipoxygenase., Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO Jr, J Am Chem Soc. 2001 Nov 7;123(44):10814-20. PMID:11686682 Page seeded by OCA on Fri May 2 20:05:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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