This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1ikn
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1ikn.gif|left|200px]] | [[Image:1ikn.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1ikn", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1ikn| PDB=1ikn | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''IKAPPABALPHA/NF-KAPPAB COMPLEX''' | '''IKAPPABALPHA/NF-KAPPAB COMPLEX''' | ||
| Line 30: | Line 27: | ||
[[Category: Huxford, T.]] | [[Category: Huxford, T.]] | ||
[[Category: Malek, S.]] | [[Category: Malek, S.]] | ||
| - | [[Category: | + | [[Category: Ikb/nfkb complex]] |
| - | [[Category: | + | [[Category: Transcription factor]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:06:16 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:06, 2 May 2008
IKAPPABALPHA/NF-KAPPAB COMPLEX
Overview
IkappaBalpha regulates the transcription factor NF-kappaB through the formation of stable IkappaBalpha/NF-kappaB complexes. Prior to induction, IkappaBalpha retains NF-kappaB in the cytoplasm until the NF-kappaB activation signal is received. After activation, NF-kappaB is removed from gene promoters through association with nuclear IkappaBalpha, restoring the preinduction state. The 2.3 A crystal structure of IkappaBalpha in complex with the NF-kappaB p50/p65 heterodimer reveals mechanisms of these inhibitory activities. The presence of IkappaBalpha allows large en bloc movement of the NF-kappaB p65 subunit amino-terminal domain. This conformational change induces allosteric inhibition of NF-kappaB DNA binding. Amino acid residues immediately preceding the nuclear localization signals of both NF-kappaB p50 and p65 subunits are tethered to the IkappaBalpha amino-terminal ankyrin repeats, impeding NF-kappaB from nuclear import machinery recognition.
About this Structure
1IKN is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation., Huxford T, Huang DB, Malek S, Ghosh G, Cell. 1998 Dec 11;95(6):759-70. PMID:9865694 Page seeded by OCA on Fri May 2 20:06:16 2008
