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Nuclear receptor coactivator

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{{STRUCTURE_1oj5| PDB=1oj5 | SIZE=400| SCENE= |right|CAPTION=Mouse nuclear receptor activator (grey) complex with STAT6 transactivator domain LXXLL peptide (green) and I-1 ions, [[1oj5]] }}
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<StructureSection load='1oj5' size='400' side='right' scene='' caption='Mouse nuclear receptor activator (grey) complex with STAT6 transactivator domain LXXLL peptide (green) and I-1 ions, [[1oj5]]'>
'''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors<ref>PMID:9121485</ref>.<br />
'''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors<ref>PMID:9121485</ref>.<br />
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*'''NCOA3''' shows histone acetyltransferase activity.<br />
*'''NCOA3''' shows histone acetyltransferase activity.<br />
*'''NCOA5''' is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.<br />
*'''NCOA5''' is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.<br />
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</StructureSection>
==3D structures of nuclear receptor coactivator==
==3D structures of nuclear receptor coactivator==

Revision as of 09:29, 22 August 2017

Mouse nuclear receptor activator (grey) complex with STAT6 transactivator domain LXXLL peptide (green) and I-1 ions, 1oj5

Drag the structure with the mouse to rotate

3D structures of nuclear receptor coactivator

1v95 – hNCOA5 – human - NMR
1kbh – hNCOA + CREB-binding protein - NMR
2c52 – hNCOA1 residues 920-970 + CREB-binding protein - NMR
1oj5 – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse

References

  1. ↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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