Nucleoplasmin
From Proteopedia
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| - | {{STRUCTURE_1k5j| PDB=1k5j | SIZE=400| SCENE= |right|CAPTION=Nucleoplasmin core | + | {{STRUCTURE_1k5j| PDB=1k5j | SIZE=400| SCENE= |right|CAPTION=Nucleoplasmin core pentamer, [[1k5j]] }} |
| - | + | == Function == | |
'''Nucleoplasmin''' (Npl) is a molecular chaperone. Npl functions in the proper assembly of nucleosomes and chromatin structures<ref>PMID:15284896</ref>. | '''Nucleoplasmin''' (Npl) is a molecular chaperone. Npl functions in the proper assembly of nucleosomes and chromatin structures<ref>PMID:15284896</ref>. | ||
| + | == Relevance == | ||
| + | Apoptotic chromatin condensation, one of the hallmarks of apoptosis, is regulated by Npl. | ||
==3D structures of nucleoplasmin== | ==3D structures of nucleoplasmin== | ||
Revision as of 09:15, 16 May 2016
Contents |
Function
Nucleoplasmin (Npl) is a molecular chaperone. Npl functions in the proper assembly of nucleosomes and chromatin structures[1].
Relevance
Apoptotic chromatin condensation, one of the hallmarks of apoptosis, is regulated by Npl.
3D structures of nucleoplasmin
1k5j – XlNpl core – Xenopus laevis
2vtx - XlNpl core (mutant)
3t30 – Npl oligomerisation domain - human
1ee5, 1ejy –XlNpl nuclear localization peptide + karyopherin-a
References
- ↑ Prado A, Ramos I, Frehlick LJ, Muga A, Ausio J. Nucleoplasmin: a nuclear chaperone. Biochem Cell Biol. 2004 Aug;82(4):437-45. PMID:15284896 doi:http://dx.doi.org/10.1139/o04-042
