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1imj

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[[Image:1imj.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imj OCA], [http://www.ebi.ac.uk/pdbsum/1imj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1imj RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE HUMAN CCG1/TAFII250-INTERACTING FACTOR B (CIB)'''
'''CRYSTAL STRUCTURE OF THE HUMAN CCG1/TAFII250-INTERACTING FACTOR B (CIB)'''
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[[Category: Kuzuhara, T.]]
[[Category: Kuzuhara, T.]]
[[Category: Padmanabhan, B.]]
[[Category: Padmanabhan, B.]]
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[[Category: alpha/beta hydrolase]]
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[[Category: Alpha/beta hydrolase]]
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[[Category: ccg1 interactor]]
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[[Category: Ccg1 interactor]]
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Revision as of 17:09, 2 May 2008

Image:1imj.jpg

Template:STRUCTURE 1imj

CRYSTAL STRUCTURE OF THE HUMAN CCG1/TAFII250-INTERACTING FACTOR B (CIB)


Overview

The general transcription initiation factor TFIID and its interactors play critical roles in regulating the transcription from both naked and chromatin DNA. We have isolated a novel TFIID interactor that we denoted as CCG1/TAF(II)250-interacting factor B (CIB). We show here that CIB activates transcription. To further understand the function of this protein, we determined its crystal structure at 2.2-Angstroms resolution. The tertiary structure of CIB reveals an alpha/beta-hydrolase fold that resembles structures in the prokaryotic alpha/beta-hydrolase family proteins. It is not similar in structure or primary sequence to any eukaryotic transcription or chromatin factors that have been reported to date. CIB possesses a conserved catalytic triad that is found in other alpha/beta-hydrolases, and our in vitro studies confirmed that it bears hydrolase activity. However, CIB differs from other alpha/beta-hydrolases in that it lacks a binding site excursion, which facilitates the substrate selectivity of the other alpha/beta-hydrolases. Further functional characterization of CIB based on its tertiary structure and through biochemical studies may provide novel insights into the mechanisms that regulate eukaryotic transcription.

About this Structure

1IMJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of CCG1/TAF(II)250-interacting factor B (CIB)., Padmanabhan B, Kuzuhara T, Adachi N, Horikoshi M, J Biol Chem. 2004 Mar 5;279(10):9615-24. Epub 2003 Dec 11. PMID:14672934 Page seeded by OCA on Fri May 2 20:09:39 2008

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