5fk9

From Proteopedia

(Difference between revisions)

Revision as of 07:23, 6 May 2020

Crystal structure of staphylococcal enterotoxin A F47A mutant in complex with a T cell receptor

Structural highlights

5fk9 is a 3 chain structure with sequence from "micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885 and Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	5fka
Gene:	ENTA ("Micrococcus aureus" (Rosenbach 1884) Zopf 1885)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ETXA_STAAU] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Publication Abstract from PubMed

Superantigens are toxins produced by Staphylococcus aureus, called staphylococcal enterotoxins (abbreviated SEA to SEU). They can cross-link the T cell receptor (TCR) and major histocompatibility complex class II, triggering a massive T cell activation and hence disease. Due to high stability and toxicity, superantigens are potential agents of bioterrorism. Hence, antagonists may not only be useful in the treatment of disease but also serve as countermeasures to biological warfare. Of particular interest are inhibitors against SEA and SEB. SEA is the main cause of food poisoning, while SEB is a common toxin manufactured as a biological weapon. Here, we present the crystal structures of SEA in complex with TCR and SEE in complex with the same TCR, complemented with computational alanine-scanning mutagenesis of SEA, SEB, SEC3, SEE, and SEH. We have identified two common areas that contribute to the general TCR binding for these superantigens. This paves the way for design of single antagonists directed towards multiple toxins.

Two common structural motifs for TCR recognition by staphylococcal enterotoxins.,Rodstrom KE, Regenthal P, Bahl C, Ford A, Baker D, Lindkvist-Petersson K Sci Rep. 2016 May 16;6:25796. doi: 10.1038/srep25796. PMID:27180909^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Rodstrom KE, Regenthal P, Bahl C, Ford A, Baker D, Lindkvist-Petersson K. Two common structural motifs for TCR recognition by staphylococcal enterotoxins. Sci Rep. 2016 May 16;6:25796. doi: 10.1038/srep25796. PMID:27180909 doi:http://dx.doi.org/10.1038/srep25796

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5fk9"

@@ Line 1: / Line 1: @@
 ==Crystal structure of staphylococcal enterotoxin A F47A mutant in complex with a T cell receptor==
-<StructureSection load='5fk9' size='340' side='right' caption='[[5fk9]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
+<StructureSection load='5fk9' size='340' side='right'caption='[[5fk9]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5fk9]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FK9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5fk9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FK9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FK9 FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fka|5fka]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fk9 OCA], [http://pdbe.org/5fk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fk9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fk9 PDBsum]</span></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ENTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fk9 OCA], [http://pdbe.org/5fk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fk9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fk9 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 18: / Line 19: @@
 </div>
 <div class="pdbe-citations 5fk9" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Lindkvist-Petersson, K]]
 [[Category: Regenthal, P]]

5fk9

From Proteopedia

Revision as of 07:23, 6 May 2020

Crystal structure of staphylococcal enterotoxin A F47A mutant in complex with a T cell receptor

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox