4xit
From Proteopedia
(Difference between revisions)
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==Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors== | ==Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors== | ||
| - | <StructureSection load='4xit' size='340' side='right' caption='[[4xit]], [[Resolution|resolution]] 1.86Å' scene=''> | + | <StructureSection load='4xit' size='340' side='right'caption='[[4xit]], [[Resolution|resolution]] 1.86Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4xit]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XIT FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4xit]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XIT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XIT FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40Z:2-CHLORO-5-(FURAN-2-YLMETHYL)-8,11,11-TRIMETHYL-9-OXO-6,7,9,10,11,12-HEXAHYDRO-5H-INDOLO[1,2-A][1,5]BENZODIAZEPINE-3-CARBOXAMIDE'>40Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40Z:2-CHLORO-5-(FURAN-2-YLMETHYL)-8,11,11-TRIMETHYL-9-OXO-6,7,9,10,11,12-HEXAHYDRO-5H-INDOLO[1,2-A][1,5]BENZODIAZEPINE-3-CARBOXAMIDE'>40Z</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xip|4xip]], [[4xir|4xir]], [[4xiq|4xiq]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xip|4xip]], [[4xir|4xir]], [[4xiq|4xiq]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xit OCA], [http://pdbe.org/4xit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xit RCSB], [http://www.ebi.ac.uk/pdbsum/4xit PDBsum]</span></td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xit OCA], [http://pdbe.org/4xit PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xit RCSB], [http://www.ebi.ac.uk/pdbsum/4xit PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xit ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Neubert, T]] | [[Category: Neubert, T]] | ||
[[Category: Zuccola, H J]] | [[Category: Zuccola, H J]] | ||
[[Category: Chaperone-chaperone inhibitor complex]] | [[Category: Chaperone-chaperone inhibitor complex]] | ||
Revision as of 07:06, 29 May 2019
Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors
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