This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2n3y
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of the Y48pCMF variant of human cytochrome c in its reduced state== | |
| - | + | <StructureSection load='2n3y' size='340' side='right' caption='[[2n3y]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2n3y]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N3Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MH0:MESOHEME'>MH0</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PA:4-(CARBOXYMETHYL)-L-PHENYLALANINE'>1PA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3y OCA], [http://pdbe.org/2n3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n3y RCSB], [http://www.ebi.ac.uk/pdbsum/2n3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CYC_HUMAN CYC_HUMAN]] Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:[http://omim.org/entry/612004 612004]]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.<ref>PMID:18345000</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CYC_HUMAN CYC_HUMAN]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Conte, R Del]] | ||
[[Category: Diaz-Moreno, I]] | [[Category: Diaz-Moreno, I]] | ||
[[Category: Diaz-Quintana, A]] | [[Category: Diaz-Quintana, A]] | ||
| - | [[Category: Del Conte, R]] | ||
[[Category: Moreno-Beltran, B]] | [[Category: Moreno-Beltran, B]] | ||
| + | [[Category: Rosa, M A.De la]] | ||
[[Category: Turano, P]] | [[Category: Turano, P]] | ||
| - | [[Category: | + | [[Category: Apoptosis]] |
| + | [[Category: Cytochrome c]] | ||
| + | [[Category: Electron transport]] | ||
| + | [[Category: Hemeprotein]] | ||
| + | [[Category: Mitochondria]] | ||
| + | [[Category: Phosphorylation]] | ||
Revision as of 19:12, 15 December 2016
NMR structure of the Y48pCMF variant of human cytochrome c in its reduced state
| |||||||||||
