1ire

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[[Image:1ire.gif|left|200px]]
[[Image:1ire.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ire |SIZE=350|CAPTION= <scene name='initialview01'>1ire</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1ire", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrile_hydratase Nitrile hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.84 4.2.1.84] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1ire| PDB=1ire | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ire FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ire OCA], [http://www.ebi.ac.uk/pdbsum/1ire PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ire RCSB]</span>
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}}
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'''Crystal Structure of Co-type nitrile hydratase from Pseudonocardia thermophila'''
'''Crystal Structure of Co-type nitrile hydratase from Pseudonocardia thermophila'''
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[[Category: Miyanaga, A.]]
[[Category: Miyanaga, A.]]
[[Category: Wakagi, T.]]
[[Category: Wakagi, T.]]
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[[Category: cysteine-sulfenic acid]]
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[[Category: Cysteine-sulfenic acid]]
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[[Category: cysteine-sulfinic acid]]
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[[Category: Cysteine-sulfinic acid]]
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[[Category: hydration]]
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[[Category: Hydration]]
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[[Category: nitrile]]
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[[Category: Nitrile]]
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[[Category: non-corrin cobalt]]
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[[Category: Non-corrin cobalt]]
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[[Category: post-translational modification]]
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[[Category: Post-translational modification]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:19:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:23:35 2008''
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Revision as of 17:19, 2 May 2008

Image:1ire.gif

Template:STRUCTURE 1ire

Crystal Structure of Co-type nitrile hydratase from Pseudonocardia thermophila


Overview

The crystal structure of cobalt-containing nitrile hydratase from Pseudonocardia thermophila JCM 3095 at 1.8 A resolution revealed the structure of the noncorrin cobalt at the catalytic center. Two cysteine residues (alphaCys(111) and alphaCys(113)) coordinated to the cobalt were posttranslationally modified to cysteine-sulfinic acid and to cysteine-sulfenic acid, respectively, like in iron-containing nitrile hydratase. A tryptophan residue (betaTrp(72)), which may be involved in substrate binding, replaced the tyrosine residue of iron-containing nitrile hydratase. The difference seems to be responsible for the preference for aromatic nitriles rather than aliphatic ones of cobalt-containing nitrile hydratase.

About this Structure

1IRE is a Protein complex structure of sequences from Pseudonocardia thermophila. Full crystallographic information is available from OCA.

Reference

Crystal structure of cobalt-containing nitrile hydratase., Miyanaga A, Fushinobu S, Ito K, Wakagi T, Biochem Biophys Res Commun. 2001 Nov 16;288(5):1169-74. PMID:11700034 Page seeded by OCA on Fri May 2 20:19:18 2008

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