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1irj

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[[Image:1irj.gif|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1irj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1irj OCA], [http://www.ebi.ac.uk/pdbsum/1irj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1irj RCSB]</span>
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'''Crystal Structure of the MRP14 complexed with CHAPS'''
'''Crystal Structure of the MRP14 complexed with CHAPS'''
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[[Category: Watanabe, N.]]
[[Category: Watanabe, N.]]
[[Category: Yao, M.]]
[[Category: Yao, M.]]
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[[Category: calgranulin b]]
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[[Category: Calgranulin b]]
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[[Category: ef-hand]]
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[[Category: Ef-hand]]
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[[Category: mrp14]]
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[[Category: Mrp14]]
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[[Category: s100a9]]
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[[Category: S100a9]]
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Revision as of 17:19, 2 May 2008

Image:1irj.gif

Template:STRUCTURE 1irj

Crystal Structure of the MRP14 complexed with CHAPS


Overview

Human MRP14 (hMRP14) is a Ca(2+)-binding protein from the S100 family of proteins. This protein is co-expressed with human MRP8 (hMRP8), a homologue protein in myeloid cells, and plays an indispensable role in Ca(2+)-dependent functions during inflammation. This role includes the activation of Mac-1, the beta(2) integrin which is involved in neutrophil adhesion to endothelial cells. The crystal structure of the holo form of hMRP14 was analyzed at 2.1 A resolution. hMRP14 is distinguished from other S100 member proteins by its long C-terminal region, and its structure shows that the region is extensively flexible. In this crystal structure of hMRP14, Chaps molecules bind to the hinge region that connects two EF-hand motifs, which suggests that this region is a target-binding site of this protein. Based on a structural comparison of hMRP14 with hMRP8 and human S100A12 (hS100A12) that is another homologue protein, the character of MRP8/14 hetero-complex and the functional significance of the flexibility of the C-terminal region of hMRP14 are discussed.

About this Structure

1IRJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory process., Itou H, Yao M, Fujita I, Watanabe N, Suzuki M, Nishihira J, Tanaka I, J Mol Biol. 2002 Feb 15;316(2):265-76. PMID:11851337 Page seeded by OCA on Fri May 2 20:19:39 2008

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