1irs

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[[Image:1irs.gif|left|200px]]
[[Image:1irs.gif|left|200px]]
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{{Structure
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|PDB= 1irs |SIZE=350|CAPTION= <scene name='initialview01'>1irs</scene>
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The line below this paragraph, containing "STRUCTURE_1irs", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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|GENE= PTB DOMAIN OF IRS-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_1irs| PDB=1irs | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1irs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1irs OCA], [http://www.ebi.ac.uk/pdbsum/1irs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1irs RCSB]</span>
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'''IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE'''
'''IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE'''
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[[Category: Trub, T.]]
[[Category: Trub, T.]]
[[Category: Zhou, M M.]]
[[Category: Zhou, M M.]]
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[[Category: complex]]
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[[Category: Complex]]
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[[Category: complex (signal transduction/peptide)]]
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[[Category: Signal transduction]]
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[[Category: phosphotyrosine binding domain (ptb)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:20:13 2008''
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[[Category: signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:23:44 2008''
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Revision as of 17:20, 2 May 2008

Image:1irs.gif

Template:STRUCTURE 1irs

IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE


Overview

We present the NMR structure of the PTB domain of insulin receptor substrate-1 (IRS-1) complexed to a tyrosine-phosphorylated peptide derived from the IL-4 receptor. Despite the lack of sequence homology and different binding specificity, the overall fold of the protein is similar to that of the Shc PTB domain and closely resembles that of PH domains. However, the PTB domain of IRS-1 is smaller than that of Shc (110 versus 170 residues) and binds to phosphopeptides in a distinct manner. We explain the phosphopeptide binding specificity based on the structure of the complex and results of site-directed mutagenesis experiments.

About this Structure

1IRS is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain., Zhou MM, Huang B, Olejniczak ET, Meadows RP, Shuker SB, Miyazaki M, Trub T, Shoelson SE, Fesik SW, Nat Struct Biol. 1996 Apr;3(4):388-93. PMID:8599766 Page seeded by OCA on Fri May 2 20:20:13 2008

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