This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1irx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1irx.gif|left|200px]]
[[Image:1irx.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1irx |SIZE=350|CAPTION= <scene name='initialview01'>1irx</scene>, resolution 2.6&Aring;
+
The line below this paragraph, containing "STRUCTURE_1irx", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1irx| PDB=1irx | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1irx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1irx OCA], [http://www.ebi.ac.uk/pdbsum/1irx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1irx RCSB]</span>
+
-
}}
+
'''Crystal structure of class I lysyl-tRNA synthetase'''
'''Crystal structure of class I lysyl-tRNA synthetase'''
Line 34: Line 31:
[[Category: Terada, T.]]
[[Category: Terada, T.]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama, S.]]
-
[[Category: alpha-helix cage]]
+
[[Category: Alpha-helix cage]]
-
[[Category: beta sandwitch]]
+
[[Category: Beta sandwitch]]
-
[[Category: riken structural genomics/proteomics initiative]]
+
[[Category: Riken structural genomics/proteomics initiative]]
-
[[Category: rossmann fold]]
+
[[Category: Rossmann fold]]
-
[[Category: rsgi]]
+
[[Category: Rsgi]]
-
[[Category: structural genomic]]
+
[[Category: Structural genomic]]
-
[[Category: zinc-binding structure]]
+
[[Category: Zinc-binding structure]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:20:31 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:23:47 2008''
+

Revision as of 17:20, 2 May 2008

Image:1irx.gif

Template:STRUCTURE 1irx

Crystal structure of class I lysyl-tRNA synthetase


Overview

Lysyl-tRNA can be synthesized by both a class I (LysRS-I) and a class II (LysRS-II) lysyl-tRNA synthetase. The crystal structure of LysRS-I from Pyrococcus horikoshii at 2.6 A resolution reveals extensive similarity with glutamyl-tRNA synthetase (GluRS). A comparison of the structures of LysRS-I and LysRS-II in complex with lysine shows that both enzymes use similar strategies for substrate recognition within unrelated active site topologies. A docking model based upon the GluRS-tRNA complex suggests how LysRS-I and LysRS-II can recognize the same molecular determinants in tRNALys, as shown by biochemical results, while approaching the acceptor helix of the tRNA from opposite sides.

About this Structure

1IRX is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Functional convergence of two lysyl-tRNA synthetases with unrelated topologies., Terada T, Nureki O, Ishitani R, Ambrogelly A, Ibba M, Soll D, Yokoyama S, Nat Struct Biol. 2002 Apr;9(4):257-62. PMID:11887185 Page seeded by OCA on Fri May 2 20:20:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1irx"
Personal tools