1irx

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[[Image:1irx.gif|left|200px]]
[[Image:1irx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1irx |SIZE=350|CAPTION= <scene name='initialview01'>1irx</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1irx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysine--tRNA_ligase Lysine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.6 6.1.1.6] </span>
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|DOMAIN=
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{{STRUCTURE_1irx| PDB=1irx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1irx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1irx OCA], [http://www.ebi.ac.uk/pdbsum/1irx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1irx RCSB]</span>
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}}
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'''Crystal structure of class I lysyl-tRNA synthetase'''
'''Crystal structure of class I lysyl-tRNA synthetase'''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:20:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:23:47 2008''
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Revision as of 17:20, 2 May 2008

Image:1irx.gif

Template:STRUCTURE 1irx

Crystal structure of class I lysyl-tRNA synthetase


Overview

Lysyl-tRNA can be synthesized by both a class I (LysRS-I) and a class II (LysRS-II) lysyl-tRNA synthetase. The crystal structure of LysRS-I from Pyrococcus horikoshii at 2.6 A resolution reveals extensive similarity with glutamyl-tRNA synthetase (GluRS). A comparison of the structures of LysRS-I and LysRS-II in complex with lysine shows that both enzymes use similar strategies for substrate recognition within unrelated active site topologies. A docking model based upon the GluRS-tRNA complex suggests how LysRS-I and LysRS-II can recognize the same molecular determinants in tRNALys, as shown by biochemical results, while approaching the acceptor helix of the tRNA from opposite sides.

About this Structure

1IRX is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Functional convergence of two lysyl-tRNA synthetases with unrelated topologies., Terada T, Nureki O, Ishitani R, Ambrogelly A, Ibba M, Soll D, Yokoyama S, Nat Struct Biol. 2002 Apr;9(4):257-62. PMID:11887185 Page seeded by OCA on Fri May 2 20:20:31 2008

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