1itb

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[[Image:1itb.gif|left|200px]]
[[Image:1itb.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1itb| PDB=1itb | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1itb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1itb OCA], [http://www.ebi.ac.uk/pdbsum/1itb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1itb RCSB]</span>
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'''TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA'''
'''TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA'''
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[[Category: Caffes, P.]]
[[Category: Caffes, P.]]
[[Category: Vigers, G P.A.]]
[[Category: Vigers, G P.A.]]
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[[Category: complex (immunoglobulin/receptor)]]
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[[Category: Glycoprotein]]
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[[Category: glycoprotein]]
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[[Category: Immunoglobulin fold]]
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[[Category: immunoglobulin fold]]
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[[Category: Receptor]]
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[[Category: receptor]]
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[[Category: Signal]]
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[[Category: signal]]
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[[Category: Transmembrane]]
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[[Category: transmembrane]]
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Revision as of 17:23, 2 May 2008

Image:1itb.gif

Template:STRUCTURE 1itb

TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA


Overview

Interleukin-1 (IL-1) is an important mediator of inflammatory disease. The IL-1 family currently consists of two agonists, IL-1alpha and IL-1beta, and one antagonist, IL-1ra. Each of these molecules binds to the type I IL-1 receptor (IL1R). The binding of IL-1alpha or IL-1beta to IL1R is an early step in IL-1 signal transduction and blocking this interaction may therefore be a useful target for the development of new drugs. Here we report the three-dimensional structure of IL-1beta bound to the extracellular domain of IL1R (s-IL1R) at 2.5 A resolution. IL-1beta binds to s-IL1R with a 1:1 stoichiometry. The crystal structure shows that s-IL1R consists of three immunoglobulin-like domains which wrap around IL-1beta in a manner distinct from the structures of previously described cytokine-receptor complexes. The two receptor-binding regions on IL-1beta identified by site-directed mutagenesis both contact the receptor: one binds to the first two domains of the receptor, while the other binds exclusively to the third domain.

About this Structure

1ITB is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta., Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ, Nature. 1997 Mar 13;386(6621):190-4. PMID:9062193 Page seeded by OCA on Fri May 2 20:23:17 2008

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