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5l3m

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m (Protected "5l3m" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5l3m is ON HOLD
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==D11 bound [S39_PQ]-IGF-II==
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<StructureSection load='5l3m' size='340' side='right' caption='[[5l3m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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Authors: Hexnerova, R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5l3m]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L3M FirstGlance]. <br>
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Description: D11 bound [S39_PQ]-IGF-II
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l3m OCA], [http://pdbe.org/5l3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l3m RCSB], [http://www.ebi.ac.uk/pdbsum/5l3m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l3m ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/IGF2_HUMAN IGF2_HUMAN]] Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS) [MIM:[http://omim.org/entry/180860 180860]]. A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age.<ref>PMID:19066168</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/IGF2_HUMAN IGF2_HUMAN]] The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.<ref>PMID:16912056</ref> Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.<ref>PMID:16912056</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Hexnerova, R]]
[[Category: Hexnerova, R]]
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[[Category: Cell cycle]]
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[[Category: Igf-ii]]

Revision as of 16:31, 10 August 2016

D11 bound [S39_PQ]-IGF-II

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