1ixs

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[[Image:1ixs.gif|left|200px]]
[[Image:1ixs.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ixs |SIZE=350|CAPTION= <scene name='initialview01'>1ixs</scene>, resolution 3.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1ixs", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ruva ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), ruvb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])
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-->
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|DOMAIN=
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{{STRUCTURE_1ixs| PDB=1ixs | SCENE= }}
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|RELATEDENTRY=[[1hqc|1HQC]], [[1ixr|1IXR]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ixs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ixs OCA], [http://www.ebi.ac.uk/pdbsum/1ixs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ixs RCSB]</span>
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}}
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'''Structure of RuvB complexed with RuvA domain III'''
'''Structure of RuvB complexed with RuvA domain III'''
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[[Category: Tsuchiya, D.]]
[[Category: Tsuchiya, D.]]
[[Category: Yamada, K.]]
[[Category: Yamada, K.]]
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[[Category: aaa-atpase domain]]
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[[Category: Aaa-atpase domain]]
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[[Category: complex with nucleotide]]
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[[Category: Complex with nucleotide]]
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[[Category: heterodimeric protein complex]]
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[[Category: Heterodimeric protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:33:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:26:06 2008''
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Revision as of 17:33, 2 May 2008

Image:1ixs.gif

Template:STRUCTURE 1ixs

Structure of RuvB complexed with RuvA domain III


Overview

We present the X-ray structure of the RuvA-RuvB complex, which plays a crucial role in ATP-dependent branch migration. Two RuvA tetramers form the symmetric and closed octameric shell, where four RuvA domain IIIs spring out in the two opposite directions to be individually caught by a single RuvB. The binding of domain III deforms the protruding beta hairpin in the N-terminal domain of RuvB and thereby appears to induce a functional and less symmetric RuvB hexameric ring. The model of the RuvA-RuvB junction DNA ternary complex, constructed by fitting the X-ray structure into the averaged electron microscopic images of the RuvA-RuvB junction, appears to be more compatible with the branch migration mode of a fixed RuvA-RuvB interaction than with a rotational interaction mode.

About this Structure

1IXS is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the RuvA-RuvB complex: a structural basis for the Holliday junction migrating motor machinery., Yamada K, Miyata T, Tsuchiya D, Oyama T, Fujiwara Y, Ohnishi T, Iwasaki H, Shinagawa H, Ariyoshi M, Mayanagi K, Morikawa K, Mol Cell. 2002 Sep;10(3):671-81. PMID:12408833 Page seeded by OCA on Fri May 2 20:33:19 2008

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OCA

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