1iyf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1iyf.gif|left|200px]]
[[Image:1iyf.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1iyf |SIZE=350|CAPTION= <scene name='initialview01'>1iyf</scene>
+
The line below this paragraph, containing "STRUCTURE_1iyf", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1iyf| PDB=1iyf | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iyf OCA], [http://www.ebi.ac.uk/pdbsum/1iyf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iyf RCSB]</span>
+
-
}}
+
'''Solution structure of ubiquitin-like domain of human parkin'''
'''Solution structure of ubiquitin-like domain of human parkin'''
Line 38: Line 35:
[[Category: Yokosawa, H.]]
[[Category: Yokosawa, H.]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama, S.]]
-
[[Category: riken structural genomics/proteomics initiative]]
+
[[Category: Riken structural genomics/proteomics initiative]]
-
[[Category: rsgi]]
+
[[Category: Rsgi]]
-
[[Category: structural genomic]]
+
[[Category: Structural genomic]]
-
[[Category: ubiquitin fold]]
+
[[Category: Ubiquitin fold]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:34:53 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:26:26 2008''
+

Revision as of 17:34, 2 May 2008

Image:1iyf.gif

Template:STRUCTURE 1iyf

Solution structure of ubiquitin-like domain of human parkin


Overview

Parkin, a product of the causative gene of autosomal-recessive juvenile parkinsonism (AR-JP), is a RING-type E3 ubiquitin ligase and has an amino-terminal ubiquitin-like (Ubl) domain. Although a single mutation that causes an Arg to Pro substitution at position 42 of the Ubl domain (the Arg 42 mutation) has been identified in AR-JP patients, the function of this domain is not clear. In this study, we determined the three-dimensional structure of the Ubl domain of parkin by NMR, in particular by extensive use of backbone (15)N-(1)H residual dipolar-coupling data. Inspection of chemical-shift-perturbation data showed that the parkin Ubl domain binds the Rpn10 subunit of 26S proteasomes via the region of parkin that includes position 42. Our findings suggest that the Arg 42 mutation induces a conformational change in the Rpn10-binding site of Ubl, resulting in impaired proteasomal binding of parkin, which could be the cause of AR-JP.

About this Structure

1IYF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain., Sakata E, Yamaguchi Y, Kurimoto E, Kikuchi J, Yokoyama S, Yamada S, Kawahara H, Yokosawa H, Hattori N, Mizuno Y, Tanaka K, Kato K, EMBO Rep. 2003 Mar;4(3):301-6. PMID:12634850 Page seeded by OCA on Fri May 2 20:34:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1iyf"
Personal tools