1iyv

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[[Image:1iyv.gif|left|200px]]
[[Image:1iyv.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1iyv |SIZE=350|CAPTION= <scene name='initialview01'>1iyv</scene>
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The line below this paragraph, containing "STRUCTURE_1iyv", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=LIP:LYS+39+Is+The+Lipoylation+Site+Where+Lipoic+Acid+(6,8+Th+...'>LIP</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1iyv| PDB=1iyv | SCENE= }}
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|RELATEDENTRY=[[1iyu|1IYU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iyv OCA], [http://www.ebi.ac.uk/pdbsum/1iyv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iyv RCSB]</span>
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}}
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'''LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COMPLEX, NMR, 29 STRUCTURES'''
'''LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COMPLEX, NMR, 29 STRUCTURES'''
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[[Category: Kok, A De.]]
[[Category: Kok, A De.]]
[[Category: Vervoort, J.]]
[[Category: Vervoort, J.]]
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[[Category: acyltransferase]]
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[[Category: Acyltransferase]]
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[[Category: glycolysis]]
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[[Category: Glycolysis]]
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[[Category: lipoyl]]
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[[Category: Lipoyl]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:36:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:26:36 2008''
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Revision as of 17:36, 2 May 2008

Image:1iyv.gif

Template:STRUCTURE 1iyv

LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COMPLEX, NMR, 29 STRUCTURES


Overview

The three-dimensional structure of the N-terminal lipoyl domain of the acetyltransferase component of the pyruvate dehydrogenase complex from Azotobacter vinelandii has been determined using heteronuclear multidimensional NMR spectroscopy and dynamical simulated annealing. The structure is compared with the solution structure of the lipoyl domain of the A. vinelandii 2-oxoglutarate dehydrogenase complex. The overall fold of the two structures, described as a beta-barrel-sandwich hybrid, is very similar. This agrees well with the high similarity of NMR-derived parameters, e.g. chemical shifts, between the two lipoyl domains. The main structural differences between the two lipoyl domains occur in a solvent-exposed loop close in space to the lipoylation site. Despite their high structural similarity, these lipoyl domains show a high preference for being reductively acylated by their parent 2-oxo acid dehydrogenase. Potential residues of the lipoyl domain involved in this process of molecular recognition are discussed.

About this Structure

1IYV is a Single protein structure of sequence from Azotobacter vinelandii. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure in solution of the N-terminal lipoyl domain of the pyruvate dehydrogenase complex from Azotobacter vinelandii., Berg A, Vervoort J, de Kok A, Eur J Biochem. 1997 Mar 1;244(2):352-60. PMID:9119000 Page seeded by OCA on Fri May 2 20:36:03 2008

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