1j0s

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j0s OCA], [http://www.ebi.ac.uk/pdbsum/1j0s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j0s RCSB]</span>
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'''Solution structure of the human interleukin-18'''
'''Solution structure of the human interleukin-18'''
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[[Category: Torigoe, K.]]
[[Category: Torigoe, K.]]
[[Category: Yoneda, T.]]
[[Category: Yoneda, T.]]
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[[Category: beta trefoil]]
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[[Category: Beta trefoil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:39:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:27:19 2008''
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Revision as of 17:39, 2 May 2008

Image:1j0s.gif

Template:STRUCTURE 1j0s

Solution structure of the human interleukin-18


Overview

Interleukin-18 (IL-18), a cytokine formerly known as interferon-gamma- (IFN-gamma-) inducing factor, has pleiotropic immunoregulatory functions, including augmentation of IFN-gamma production, Fas-mediated cytotoxicity and developmental regulation of T-lymphocyte helper type I. We determined the solution structure of IL-18 as a first step toward understanding its receptor activation mechanism. It folds into a beta-trefoil structure that resembles that of IL-1. Extensive mutagenesis revealed the presence of three sites that are important for receptor activation: two serve as binding sites for IL-18 receptor alpha (IL-18Ralpha), located at positions similar to those of IL-1 for IL-1 receptor type I (IL-1RI), whereas the third site may be involved in IL-18 receptor beta (IL-18Rbeta) binding. The structure and mutagenesis data provide a basis for understanding the IL-18-induced heterodimerization of receptor subunits, which is necessary for receptor activation.

About this Structure

1J0S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure and binding mode of interleukin-18., Kato Z, Jee J, Shikano H, Mishima M, Ohki I, Ohnishi H, Li A, Hashimoto K, Matsukuma E, Omoya K, Yamamoto Y, Yoneda T, Hara T, Kondo N, Shirakawa M, Nat Struct Biol. 2003 Nov;10(11):966-71. Epub 2003 Oct 5. PMID:14528293 Page seeded by OCA on Fri May 2 20:39:49 2008

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