P63
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | ''' | + | '''p63''' is a tumor protein belonging to the p53 family. It is a multi-isoform protein required for epidermal development<ref>PMID:10594758</ref>. p63 domains structure is similar to that of p53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the p63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions. |
== Disease == | == Disease == | ||
| - | Mutations in | + | Mutations in p63 result in cleft lip or palate syndromes, split hand/foot malformation or ectodermal dysplasia<ref>PMID:16740912</ref>, <ref>PMID:23407076</ref>. |
== Relevance == | == Relevance == | ||
| - | One isoform of | + | One isoform of p63 is involved in skin development and stem/progenitor cell regulation<ref>PMID:17224652</ref>. Another isoform functions in apoptosis<ref>PMID:16998800</ref>. |
</StructureSection> | </StructureSection> | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | * | + | *p63 DBD |
**[[2rmn]] – hP63 - human - NMR<br /> | **[[2rmn]] – hP63 - human - NMR<br /> | ||
**[[3qym]], [[3qyn]], [[3us0]], [[3us1]], [[3us2]] – hP63 + DNA<br /> | **[[3qym]], [[3qyn]], [[3us0]], [[3us1]], [[3us2]] – hP63 + DNA<br /> | ||
| - | * | + | *p63 tetramerization domain |
**[[3zy0]], [[3zy1]], [[4a9z]] – hP63 <br /> | **[[3zy0]], [[3zy1]], [[4a9z]] – hP63 <br /> | ||
| - | * | + | *p63 C terminal domain |
**[[1rg6]] – hP63 - NMR<br /> | **[[1rg6]] – hP63 - NMR<br /> | ||
| - | * | + | *p63 SAM domain |
**[[2y9t]] – hP63 - NMR<br /> | **[[2y9t]] – hP63 - NMR<br /> | ||
Revision as of 10:08, 13 June 2016
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3D Structures of P63
Updated on 13-June-2016
References
- ↑ Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol. 1999 Dec;113(6):1099-105. PMID:10594758 doi:http://dx.doi.org/10.1046/j.1523-1747.1999.00780.x
- ↑ Leoyklang P, Siriwan P, Shotelersuk V. A mutation of the p63 gene in non-syndromic cleft lip. J Med Genet. 2006 Jun;43(6):e28. PMID:16740912 doi:43/6/e28
- ↑ Tadini G, Santagada F, Brena M, Pezzani L, Nannini P. Ectodermal dysplasias: the p63 tail. G Ital Dermatol Venereol. 2013 Feb;148(1):53-8. PMID:23407076
- ↑ Koster MI, Dai D, Roop DR. Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle. 2007 Feb 1;6(3):269-73. Epub 2007 Feb 3. PMID:17224652 doi:http://dx.doi.org/10.4161/cc.6.3.3792
- ↑ Petre-Lazar B, Livera G, Moreno SG, Trautmann E, Duquenne C, Hanoux V, Habert R, Coffigny H. The role of p63 in germ cell apoptosis in the developing testis. J Cell Physiol. 2007 Jan;210(1):87-98. PMID:16998800 doi:http://dx.doi.org/10.1002/jcp.20829
