Pantothenate kinase
From Proteopedia
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| - | + | <StructureSection load='2f9w' size='450' side='right' caption='Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, [[2f9w]]' scene='' pspeed='8'> | |
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== Function == | == Function == | ||
'''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis<ref>. PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959</ref>.<br /> | '''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis<ref>. PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959</ref>.<br /> | ||
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Pantothenate binds in a buried pocket at the PanK dimer interface<ref>PMID:16905099</ref>. | Pantothenate binds in a buried pocket at the PanK dimer interface<ref>PMID:16905099</ref>. | ||
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==3D structures of pantothenate kinase== | ==3D structures of pantothenate kinase== | ||
Revision as of 10:55, 25 April 2017
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3D structures of pantothenate kinase
Updated on 25-April-2017
References
- ↑ . PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959
- ↑ Pellecchia MT, Valente EM, Cif L, Salvi S, Albanese A, Scarano V, Bonuccelli U, Bentivoglio AR, D'Amico A, Marelli C, Di Giorgio A, Coubes P, Barone P, Dallapiccola B. The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration. Neurology. 2005 May 24;64(10):1810-2. PMID:15911822 doi:http://dx.doi.org/10.1212/01.WNL.0000161843.52641.EC
- ↑ Hong BS, Yun MK, Zhang YM, Chohnan S, Rock CO, White SW, Jackowski S, Park HW, Leonardi R. Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties. Structure. 2006 Aug;14(8):1251-61. PMID:16905099 doi:10.1016/j.str.2006.06.008
