1j2f

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[[Image:1j2f.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1j2f", creates the "Structure Box" on the page.
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2f OCA], [http://www.ebi.ac.uk/pdbsum/1j2f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j2f RCSB]</span>
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'''X-ray crystal structure of IRF-3 and its functional implications'''
'''X-ray crystal structure of IRF-3 and its functional implications'''
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[[Category: Takahasi, K.]]
[[Category: Takahasi, K.]]
[[Category: Terasawa, H.]]
[[Category: Terasawa, H.]]
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[[Category: transcription factor]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:43:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:28:00 2008''
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Revision as of 17:43, 2 May 2008

Image:1j2f.jpg

Template:STRUCTURE 1j2f

X-ray crystal structure of IRF-3 and its functional implications


Overview

Transcription factor IRF-3 is post-translationally activated by Toll-like receptor (TLR) signaling and has critical roles in the regulation of innate immunity. Here we present the X-ray crystal structure of the C-terminal regulatory domain of IRF-3(175-427) (IRF-3 175C) at a resolution of 2.3 A. IRF-3 175C is structurally similar to the Mad homology domain 2 of the Smad family. Structural and functional analyses reveal phosphorylation-induced IRF-3 dimerization, which generates an extensive acidic pocket responsible for binding with p300/CBP. Although TLR and Smad signaling are evolutionarily independent, our results suggest that IRF-3 originates from Smad and acquires its function downstream of TLR.

About this Structure

1J2F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of IRF-3 and its functional implications., Takahasi K, Suzuki NN, Horiuchi M, Mori M, Suhara W, Okabe Y, Fukuhara Y, Terasawa H, Akira S, Fujita T, Inagaki F, Nat Struct Biol. 2003 Nov;10(11):922-7. Epub 2003 Oct 12. PMID:14555995 Page seeded by OCA on Fri May 2 20:43:22 2008

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