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Peptide N-glycanase

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== Function ==
== Function ==
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'''Peptide N-glycanase''' (PNG) cleaves oligosaccharides from misfolded proteins and prepares them for degradation. PNG cleaves at β-aspartyl glucosamine bond to remove a glycan moiety from glycoprotein substrate<ref>PMID:17116467</ref>. PNG is present in prokaryotes and eukaryotes. PNG N terminal PUB domain interacts with the AAA ATPase protein p97 is a central component in the ubiquitin-proteasome system. '''Peptide N-glycanase F''' cleaves Asn-GlcNac bond in N-linked glycoproteins and glycopeptides<ref>PMID:7881905</ref>.
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'''Peptide N-glycanase''' (PNG) cleaves oligosaccharides from misfolded proteins and prepares them for degradation. PNG cleaves at β-aspartyl glucosamine bond to remove a glycan moiety from glycoprotein substrate<ref>PMID:17116467</ref>. PNG is present in prokaryotes and eukaryotes. PNG N terminal PUB domain interacts with the AAA ATPase protein p97 which is a central component in the ubiquitin-proteasome system. '''Peptide N-glycanase F''' cleaves Asn-GlcNac bond in N-linked glycoproteins and glycopeptides<ref>PMID:7881905</ref>.
== Disease ==
== Disease ==

Revision as of 09:01, 20 June 2016

Yeast PNGase catalytic domain (grey) complex with Rad23 (green), Zn+2 (grey) and Cl- (green) ions (PDB code 2f4m).

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3D Structures of PNGase

Updated on 20-June-2016

References

  1. ↑ Tanabe K, Lennarz WJ, Suzuki T. A cytoplasmic peptide: N-glycanase. Methods Enzymol. 2006;415:46-55. PMID:17116467 doi:http://dx.doi.org/10.1016/S0076-6879(06)15004-1
  2. ↑ Norris GE, Stillman TJ, Anderson BF, Baker EN. The three-dimensional structure of PNGase F, a glycosylasparaginase from Flavobacterium meningosepticum. Structure. 1994 Nov 15;2(11):1049-59. PMID:7881905
  3. ↑ Suzuki T. The cytoplasmic peptide:N-glycanase (Ngly1)-basic science encounters a human genetic disorder. J Biochem. 2015 Jan;157(1):23-34. doi: 10.1093/jb/mvu068. Epub 2014 Nov 13. PMID:25398991 doi:http://dx.doi.org/10.1093/jb/mvu068

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