5jcp
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==RhoGAP domain of ARAP3 in complex with RhoA in the transition state== | |
| - | + | <StructureSection load='5jcp' size='340' side='right' caption='[[5jcp]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5jcp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JCP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JCP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jcp OCA], [http://pdbe.org/5jcp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jcp RCSB], [http://www.ebi.ac.uk/pdbsum/5jcp PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ARAP3_HUMAN ARAP3_HUMAN]] Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.<ref>PMID:11804589</ref> <ref>PMID:15569923</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bao, H]] | ||
| + | [[Category: Jiang, Y]] | ||
| + | [[Category: Li, F]] | ||
| + | [[Category: Shi, Y]] | ||
| + | [[Category: Tang, Y]] | ||
| + | [[Category: Wang, C]] | ||
| + | [[Category: Wang, N]] | ||
| + | [[Category: Wu, J]] | ||
| + | [[Category: Arap3]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Rhoa]] | ||
| + | [[Category: Rhogap]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 23:28, 23 June 2016
RhoGAP domain of ARAP3 in complex with RhoA in the transition state
| |||||||||||
