5l4e
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopental== | |
| - | + | <StructureSection load='5l4e' size='340' side='right' caption='[[5l4e]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5l4e]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L4E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=EDP:5-ETHYL-5-[(2R)-PENTAN-2-YL]-2-THIOXODIHYDROPYRIMIDINE-4,6(1H,5H)-DIONE'>EDP</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l4e OCA], [http://pdbe.org/5l4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l4e RCSB], [http://www.ebi.ac.uk/pdbsum/5l4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l4e ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Delarue, M]] | ||
[[Category: Fourati, Z]] | [[Category: Fourati, Z]] | ||
| - | [[Category: Ruza, R | + | [[Category: Ruza, R R]] |
| - | [[Category: | + | [[Category: Barbiturate]] |
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 21:43, 22 December 2016
X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopental
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