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5i8p

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==Crystal structure of LP_PLA2 in complex with novel inhibitor==
==Crystal structure of LP_PLA2 in complex with novel inhibitor==
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<StructureSection load='5i8p' size='340' side='right' caption='[[5i8p]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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<StructureSection load='5i8p' size='340' side='right'caption='[[5i8p]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5i8p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I8P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I8P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5i8p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I8P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5I8P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VQ7:6-[1,1-BIS(OXIDANYLIDENE)-1,4-THIAZINAN-4-YL]-4-[[4-[4-CHLORANYL-3-(TRIFLUOROMETHYL)PHENOXY]-3,5-BIS(FLUORANYL)PHENYL]METHOXY]-1-METHYL-PYRIMIDIN-2-ONE'>VQ7</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VQ7:6-[1,1-BIS(OXIDANYLIDENE)-1,4-THIAZINAN-4-YL]-4-[[4-[4-CHLORANYL-3-(TRIFLUOROMETHYL)PHENOXY]-3,5-BIS(FLUORANYL)PHENYL]METHOXY]-1-METHYL-PYRIMIDIN-2-ONE'>VQ7</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i9i|5i9i]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i9i|5i9i]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLA2G7, PAFAH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-alkyl-2-acetylglycerophosphocholine_esterase 1-alkyl-2-acetylglycerophosphocholine esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.47 3.1.1.47] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-alkyl-2-acetylglycerophosphocholine_esterase 1-alkyl-2-acetylglycerophosphocholine esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.47 3.1.1.47] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i8p OCA], [http://pdbe.org/5i8p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i8p RCSB], [http://www.ebi.ac.uk/pdbsum/5i8p PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5i8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i8p OCA], [http://pdbe.org/5i8p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i8p RCSB], [http://www.ebi.ac.uk/pdbsum/5i8p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i8p ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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</div>
</div>
<div class="pdbe-citations 5i8p" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5i8p" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: 1-alkyl-2-acetylglycerophosphocholine esterase]]
[[Category: 1-alkyl-2-acetylglycerophosphocholine esterase]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Liu, Q F]]
[[Category: Liu, Q F]]
[[Category: Xu, Y C]]
[[Category: Xu, Y C]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Lp_pla2 inhibitor]]
[[Category: Lp_pla2 inhibitor]]

Revision as of 07:08, 3 June 2020

Crystal structure of LP_PLA2 in complex with novel inhibitor

PDB ID 5i8p

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