Pertussis toxin
From Proteopedia
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| - | {{STRUCTURE_1prt| PDB=1prt | SIZE=400| SCENE= |right|CAPTION=Pertussis toxin, [[1prt]] }} | ||
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| + | <StructureSection load='1prt' size='350' side='right' caption='Pertussis toxin (PDB entry [[1prt]])' scene=''> | ||
== Function == | == Function == | ||
'''Pertussis toxin''' (PT) is produced by the bacterium ''Bordetella pertussis'' and is the cause of whooping cough<ref>PMID:15845471</ref>. For additional details see [[Pertussis Toxin-ATP Complex]].<br /> | '''Pertussis toxin''' (PT) is produced by the bacterium ''Bordetella pertussis'' and is the cause of whooping cough<ref>PMID:15845471</ref>. For additional details see [[Pertussis Toxin-ATP Complex]].<br /> | ||
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== Relevance == | == Relevance == | ||
PT is associated with exacerbated host airway response during whooping cough infection and may inhibit host mechanisms of attenuating inflammation of the airways<ref>PMID:23027529</ref>. | PT is associated with exacerbated host airway response during whooping cough infection and may inhibit host mechanisms of attenuating inflammation of the airways<ref>PMID:23027529</ref>. | ||
| - | + | </StructureSection> | |
== 3D Structures of Pertussis toxin == | == 3D Structures of Pertussis toxin == | ||
Revision as of 06:40, 31 August 2017
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3D Structures of Pertussis toxin
1prt – BpPT - Bordetella pertussis
1pto – BpPT + galactose
1bcp – BpPT + ATP
Pertactin
1dab - BpPer
2iou - Per extracellular domain + major tropism determinant - Bordetella bronchiseptica
References
- ↑ Carbonetti NH, Artamonova GV, Andreasen C, Bushar N. Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract. Infect Immun. 2005 May;73(5):2698-703. PMID:15845471 doi:http://dx.doi.org/10.1128/IAI.73.5.2698-2703.2005
- ↑ Connelly CE, Sun Y, Carbonetti NH. Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection. Infect Immun. 2012 Dec;80(12):4317-32. doi: 10.1128/IAI.00808-12. Epub 2012 Oct, 1. PMID:23027529 doi:http://dx.doi.org/10.1128/IAI.00808-12
