Phenylethanolamine N-methyltransferase
From Proteopedia
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| + | <StructureSection load='3hcb' size='350' side='right' caption='Human phenylethanolamine N-methyltransferase with adenosyl homocysteine dimer complex with substrate noradrenochrome (PDB entry [[3hcb]])' scene=''> | ||
== Function == | == Function == | ||
[[Phenylethanolamine N-methyltransferase]] (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline). This is the last step in the conversion of tyrosine to adrenaline<ref>PMID:19570037</ref>. S-adenosyl-L-homocysteine (AdoHcy) by itself or with other ligands are inhibitors of PNMT. | [[Phenylethanolamine N-methyltransferase]] (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline). This is the last step in the conversion of tyrosine to adrenaline<ref>PMID:19570037</ref>. S-adenosyl-L-homocysteine (AdoHcy) by itself or with other ligands are inhibitors of PNMT. | ||
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==Relevance == | ==Relevance == | ||
PNMT activity is decreased in Alzheimer disease patients<ref>PMID:3662456</ref>. | PNMT activity is decreased in Alzheimer disease patients<ref>PMID:3662456</ref>. | ||
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| + | == Structural highlights == | ||
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== 3D Structures of Phenylethanolamine N-methyltransferase == | == 3D Structures of Phenylethanolamine N-methyltransferase == | ||
Revision as of 10:26, 22 June 2016
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3D Structures of Phenylethanolamine N-methyltransferase
Updated on 22-June-2016
3kpj – hPNMT+AdoHcy – human
3kpu, 3kpv, 3kpw, 3kpy, 3kqm, 3kqo, 3kqp, 3kqq, 3kqs, 3kqt, 3kqv, 3kqw, 3kqy, 3kr0, 3kr1, 3kr2, 3hcb, 3hcc, 3hcf, 2ony, 2g70, 2g71, 2g8n, 2an5, 1yz3, 1n7i, 1n7j, 1hnn - hPNMT+AdoHcy+ligand
3hca, 3hce, 2obf, 2onz, 2obp - hPNMT (mutant)+AdoHcy+ligand
3hcd - hPNMT+AdoHcy+noradrenaline
2g72 - hPNMT+AdoMet+ligand
2opb - hPNMT+AdoMet + inhibitor
2an3 - hPNMT+AdoHcy+substrate analog
2an4 - hPNMT+AdoHcy+octopamine
4dm3 - hPNMT+AdoHcy + resorcinol + imidazole
4mik, 4mq4 – hPNMT + inhibitor
References
- ↑ Drinkwater N, Gee CL, Puri M, Criscione KR, McLeish MJ, Grunewald GL, Martin JL. Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem J. 2009 Aug 27;422(3):463-71. PMID:19570037 doi:10.1042/BJ20090702
- ↑ Burke WJ, Chung HD, Nakra BR, Grossberg GT, Joh TH. Phenylethanolamine N-methyltransferase activity is decreased in Alzheimer's disease brains. Ann Neurol. 1987 Aug;22(2):278-80. PMID:3662456 doi:http://dx.doi.org/10.1002/ana.410220216
